منابع مشابه
Engineering the Bacterial Microcompartment Domain for Molecular Scaffolding Applications
As synthetic biology advances the intricacy of engineered biological systems, the importance of spatial organization within the cellular environment must not be marginalized. Increasingly, biological engineers are investigating means to control spatial organization within the cell, mimicking strategies used by natural pathways to increase flux and reduce cross-talk. A modular platform for const...
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Mycobacterium tuberculosis (Mtb) uses maltose-1-phosphate to synthesize α-glucans that make up the major component of its outer capsular layer. Maltose kinase (MaK) catalyzes phosphorylation of maltose. The molecular basis for this phosphorylation is currently not understood. Here, we describe the first crystal structure of MtbMaK refined to 2.4 Å resolution. The bi-modular architecture of MtbM...
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The scaffolding metaphor was originally developed to describe the support given by a more expert individual in a one-on-one interaction. Since then, the notion of scaffolding has been applied more broadly, and it has been transformed and generalized. Most recently, it has been used by researchers in the learning sciences to describe features and functions of technological artifacts, especially ...
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We propose a novel class of algorithms for autonomously assembling structures from inert building blocks guided by intelligent scaffolding components. Intelligent scaffold units are equipped with sensing, actuation, computation and communication abilities and facilitate the attachment of inert building blocks to the structure. After attaching an inert building block, the scaffold structure reco...
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MOTIVATION Sequencing projects increasingly target samples from non-clonal sources. In particular, metagenomics has enabled scientists to begin to characterize the structure of microbial communities. The software tools developed for assembling and analyzing sequencing data for clonal organisms are, however, unable to adequately process data derived from non-clonal sources. RESULTS We present ...
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ژورنال
عنوان ژورنال: Nature
سال: 1993
ISSN: 0028-0836,1476-4687
DOI: 10.1038/361118d0